Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 100 UG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for ADAMTS13 assay, with excitation at 340 nm and emission at 450 nm. It is utilized as a predictive tool for thrombotic thrombocytopenic purpura. This product is a light yellow to yellow solid with a molecular weight of 8314.28 and a purity of 97.3%.
- Serves as a fluorogenic substrate for ADAMTS13 assay
- Utilized as a predictive tool for thrombotic thrombocytopenic purpura
- Purity confirmed by HPLC
- Light yellow to yellow solid appearance
Medchemexpress LLC ACV Tripeptide TFA | 477.45 | 25 MG
ACV Tripeptide TFA is a tripeptide that serves as the initial dedicated intermediate in the biosynthetic pathway leading to penicillin and cephalosporin classes of β-lactam natural products in bacteria and fungi. It is nonribosomally synthesized by the ACV synthetase (ACVS) enzyme, encoded by the 11 kb *pchAB* gene, and can be used for the biosynthesis of β-lactam antibiotics. This tripeptide contains the unusual amino acid α-aminoadipic acid (α-AAA), along with L-cysteine and D-valine.
- Tripeptide
- Initial intermediate in β-lactam biosynthesis
- Synthesized by ACV synthetase (ACVS) enzyme
- Contains α-aminoadipic acid (α-AAA), L-cysteine, and D-valine
- Molecular weight: 477.45
- Formula: C16H26F3N3O8S
- Appearance: Solid
Medchemexpress LLC Crotamine (TFA) | 98.1% | 4883.73 | 5 MG
Crotamine TFA is a Na+ channel modulator. It is a 42 amino acid toxin cross-linked by three disulfide bridges. It has analgesic activity and also interacts with lipid membranes, showing myonecrotic activity. Crotamine can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes
- Shows myonecrotic activity
- Isolated from *Crotalus durissus terrificus* venom
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC), 76-05-1, MFCD00004169
Trifluoroacetic acid puriss. p.a., for HPLC, 99.0 (GC)
Hampton Research 50% W/V POLYETHYLENE GL 200ML
HR2-607/50% w/v Polyethylene glycol 10,000 - 200 ml. Please note items from this supplier are non-returnable.
Medchemexpress LLC P4pal10 TFA | 98.25% | 1409.72 | 5 MG
P4pal10 TFA is the TFA salt form of P4pal10. It acts as an antagonist for protease-activated receptor 4 (PAR4). It inhibits platelet aggregation, tissue factor (TF)-induced thrombin generation, and demonstrates anticoagulant and antithrombotic activities. Additionally, it reduces edema and granulocyte infiltration induced by Carrageenan and ameliorates injury in rats with myocardial ischemia/reperfusion (I/R) models.
- Antagonist for protease-activated receptor 4 (PAR4)
- Inhibits platelet aggregation
- Inhibits tissue factor (TF)-induced thrombin generation
- Demonstrates anticoagulant and antithrombotic activities
- Reduces edema and granulocyte infiltration
- Ameliorates injury in myocardial ischemia/reperfusion (I/R) models