Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Wl47 (TFA) | 99.7% | 1942.32 | 5 MG
WL47 TFA is a high-affinity cavolin-1 (CAV1) ligand that potently disrupts CAV1 oligomers. It shows selectivity for CAV1 over BSA, casein, and HEWL, and is used for studying caveolin-1 function. It is also 80% smaller in length than the original T20 parent sequence.
- High-affinity cavolin-1 (CAV1) ligand (Kd=23 nM)
- Potently disrupts CAV1 oligomers
- Exhibits selectivity for CAV1 over BSA, casein, and HEWL
- Used for studying caveolin-1 function
- 80% smaller in length than original T20 parent sequence
Medchemexpress LLC Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Astressin 2B TFA | 99.5% | 4041.69 (free base) | 5 MG
Medchemexpress LLC PBX-7011 TFA | 98.6% | 561.46 | 5 MG
PBX-7011 TFA is a derivative of camptothecin. It inhibits expressions of the cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells, degrades DDX5 proteins, and exhibits anticancer activity.
- Inhibits expressions of cancer-related survival genes DDX5, Survivin, Mcl-1, and XIAP in FaDu cells.
- Degrades DDX5 proteins.
- Exhibits anticancer activity.
Medchemexpress LLC Egfr-in-1 Tfa | 2753348-63-7 | 99.4% | 628.60 | 1 ML
Egfr-in-1 Tfa | 2753348-63-7 | 99.4% | 628.60 | 1 ML
Medchemexpress LLC L-lysyl-L-cysteine trifluoroacetate | 97.8% | 477.38 g/mol | C13H21F6N3O7S | 5 MG
L-lysyl-L-cysteine trifluoroacetate is a dipeptide formed from lysine and cysteine, provided as a solid TFA salt for research use. The material is characterized by a reported purity, defined molecular formula and molecular weight, and specified storage recommendations for powder and solutions.
- Dipeptide composed of lysine and cysteine.
- Supplied as trifluoroacetate (TFA) salt in solid powder form.
- Reported purity 97.8%.
- Molecular formula C13H21F6N3O7S and molecular weight 477.38 g/mol.
- Available in small research quantities: 5 mg, 10 mg, 25 mg.
- Store sealed, away from moisture; powder: -80°C for 2 years, -20°C for 1 year; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Ela-32(human) (tfa) | 99.9% | 3967.82 | 1 MG
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist with an IC50 of 0.27 nM and a Kd of 0.51 nM. This product does not bind to GPR15 and GPR25. It activates the PI3K/AKT pathway, promoting the self-renewal of hESCs via cell-cycle progression and protein translation. Additionally, it potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage, and stimulates angiogenesis in HUVEC cells.
- Potent, high affinity apelin receptor agonist
- IC50 of 0.27 nM and a Kd of 0.51 nM
- Exhibits no binding to GPR15 and GPR25
- Activates the PI3K/AKT pathway
- Promotes self-renewal of hESCs via cell-cycle progression and protein translation
- Potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage
- Stimulates angiogenesis in HUVEC cells
Medchemexpress LLC Guangxitoxin 1E TFA | ≥95.0% | 3948.61 | 100 UG
Guangxitoxin 1E TFA is the trifluoroacetate salt form of Guangxitoxin 1E, a peptide toxin. It functions as a potent and selective blocker of voltage-gated potassium channels KV2.1 and KV2.2, with an IC50 of 1-3 nM. This compound is intended for research purposes only and is not for human therapeutic use.
- Potent and selective blocker of KV2.1 and KV2.2 channels (IC50 of 1-3 nM)
- Inhibits KV4.3 channels (IC50 of 24-54 nM)
- Inhibits 90% of IDR in mouse β-cells
- Shifts voltage dependence of channel activation to more depolarized potentials
- Broadens β-cell action potential
- Enhances glucose-stimulated intracellular calcium oscillations
- Increases insulin secretion from mouse pancreatic islets in a glucose-dependent manner
Medchemexpress LLC MM-102 trifluoroacetate | 1883545-52-5 | 99.7% | 2 MG
MM-102 TFA is the trifluoroacetate salt of MM-102, a research reagent that inhibits the WDR5/MLL protein-protein interaction. It is supplied as high-purity solid and as DMSO solution formats for biochemical and cellular studies, with reported potency in WDR5 binding assays.
- Potent inhibitor of the WDR5/MLL protein-protein interaction.
- Reported IC50 = 2.4 nM in WDR5 binding assay.
- High reported purity (99.68%).
- Available in small solid quantities and as 10 mM in DMSO solution.
- Trifluoroacetate salt form for convenient handling and solubility.
Medchemexpress LLC Claramine (TFA) | 3030428-57-7 | 95.0% | 703.02 | 25 MG
Claramine TFA is a steroidal polyamine. It can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
- Steroidal polyamine
- Regulates the properties of lipid membranes
- Protects cells from various biological toxins
Medchemexpress LLC Ala-MPSD TFA | 98.02% | 3016.76 | 5 MG
Ala-MPSD TFA is a control peptide for MPSD (HY-P10471). In Ala-MPSD TFA, the four serine residues of MPSD are substituted by alanines.
- Control peptide for MPSD (HY-P10471)
- Four serine residues of MPSD are substituted by alanines
- Molecular formula: C147H243N41O27.XC2HF3O2
- Sequence: Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ala-Phe-Lys-Lys-Ala-Phe-Lys-Leu-Ala-Gly-Phe-Ala-Phe-Lys-Lys-Asn-Lys-Lys
- Purity: 98.02% (HPLC)
- Appearance: White to off-white (solid)
- MS consistent with structure
Medchemexpress LLC mP6 (TFA) | 2700321-79-3 | 990.15 | 1 MG
mP6 (Myr-FEEERA-OH) is a myristoylated peptide that functions as an Integrin β(3) Inhibitor. It inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. Additionally, mP6 blocks the GTP usage of Rac1, Rap1, and Rab7, which effectively inhibits the infection of CHO-A24 cells.
- Myristoylated peptide
- Functions as an Integrin β(3) Inhibitor
- Inhibits the interaction of Gα13 with integrin β3
- Does not disrupt talin-dependent integrin function
- Blocks the GTP usage of Rac1, Rap1, and Rab7
- Effectively inhibits the infection of CHO-A24 cells
Medchemexpress LLC GpTx-1 TFA | 1661050-12-9 | 99.6% | 4073.82 | 100 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. This compound also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM).
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Selective for NaV1.4 (IC50 = 0.301 μM).
- Selective for NaV1.5 (IC50 = 4.20 μM).
- IC50 for NaV1.3 is 0.0203 μM.
- IC50 for NaV1.8 is 12.2 μM.