Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC GRL-1720 TFA | 2835511-03-8 | C16H12ClF3N2O4 | 5 MG
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro, exhibiting anti-SARS-CoV2 activity with an EC50 value of 15 μM. This compound has a molecular weight of 388.73 and appears as a solid, ranging from light brown to brown in color.
- High purity of 98.94%.
- Shipped at room temperature.
- Store at -20°C, sealed, away from moisture.
- In solution, stable for 6 months at -80°C or 1 month at -20°C with sealed storage, away from moisture.
Medchemexpress LLC FRETS-VWF73 TFA | 97.4% | 9340.61 | 5 MG
FRETS-VWF73 TFA is a 73-amino-acid peptide that functions as a fluorogenic substrate for ADAMTS13 assay.
- 73-amino-acid peptide
- Fluorogenic substrate for ADAMTS13 assay
- Excitation at 340 nm
- Emission at 450 nm
Apexbio Technology LLC SUPER-TDU-TFA-5MG
Super-TDU TFA (CAS No 1599441-71-0) is an advanced compound frequently used in the biomedical research field particularly known for its role in investigating intracellular signaling pathways and targeting specific cellular proteins Originating from cutting-edge chemical synthesis it primarily operates by modulating specific enzymatic pathways making it a crucial tool for studying cellular mechanisms Known for its high potency this compound exhibits in vitro activity ranging from nanomolar to low micromolar concentrations facilitating precise experimental data It is widely employed in various research applications including cell models and animal studies and is integral to drug screening processes for identifying potential therapeutic candidates Experimental concentrations typically depend on the specific research design
Medchemexpress LLC TP0628103 (TFA) | 2865106-78-9 | 99.6% | 1248.68 | 5 MG
TP0628103 (Compound 18) TFA is a selective inhibitor of MMP-7, with an IC50 value of 0.17 nM. MMP-7 plays an important role in cancer and fibrosis.
- Selective inhibitor of MMP-7
- IC50 value of 0.17 nM
- Plays an important role in cancer and fibrosis research
- For research use only
Medchemexpress LLC W1131 TFA 10mM | 2740522-79-4 | C₂₅H₂₀F₃NO₈ | 1 ML
W1131 TFA is a potent STAT3 inhibitor and ferroptosis inducer. It demonstrates anti-cancer properties by inhibiting tumor growth and alleviating chemoresistance in gastric cancer models. W1131 TFA regulates critical cellular processes including the cell cycle, DNA damage response, and oxidative phosphorylation, specifically impacting the IL6-JAK-STAT3 and ferroptosis pathways.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Modulates oxidative phosphorylation
- Impacts IL6-JAK-STAT3 pathway
- Affects ferroptosis pathway
Medchemexpress LLC Lysylcysteine TFA | 97.8% | 477.38 | 25 MG
Lysylcysteine TFA (L-Lysyl-L-cysteine TFA) is a dipeptide composed of lysine and cysteine, intended for research use only. It is not for human use. This product is provided as a white to off-white solid with a high purity of 97.84% and a molecular weight of 477.38. It is shipped at room temperature in the continental US and requires sealed storage away from moisture.
- High purity: 97.84%
- Molecular weight: 477.38
- Dipeptide composed of lysine and cysteine
- Appearance: White to off-white solid
- Sequence: Lys-Cys
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC VU0364572 TFA | 1240514-89-9 | 99.3% | 487.51 | 1 ML
VU0364572 TFA is an orally active, selective, allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Acts as an orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Features an EC50 of 0.11 μM.
- Demonstrates neuroprotective potential.
- Aids in preventing memory impairments and reducing neuropathology in Alzheimer's Disease.
- Is CNS penetrant.
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438128-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML
PSEM 89S TFA is a selective and brain-penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance (HC).
- Reversibly silenced transfected neurons by reducing cellular input resistance.
- Strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F-glycine receptor (GlyR).
- Shows good brain penetrance in mice after minimally invasive intraperitoneal administration.
- Almost completely suppressed fos in ChR2-expressing neurons in male Agrp-cre mice.
- Rises rapidly in serum and brain, and is mostly cleared from both compartments in 1 hour in C57BL/6 mice.
Medchemexpress LLC Ncgc00138783 tfa | 896700-07-5 | 99.4% | C28H27F4N7O3S | 1 MG
Ncgc00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis, with an IC50 of 50 μM. It directly blocks the interaction between the CD47 and SIRPα axis.
- Target: CD47/SIRPα axis
- Selective inhibitor
- Blocks CD47/SIRPα interaction
- Molecular weight: 617.62
- Appearance: Solid, white to light yellow
- Purity: 99.4%
- Applications in immunology/inflammation
Medchemexpress LLC Gln-AMS TFA | 99.85% | 588.47 | 50 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It specifically inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. This product is intended for research use only.
- Inhibits glutaminyl-tRNA synthetase.
- High purity of 99.85%.
- Available in various quantities.
- Data sheet, COA, SDS, and handling instructions provided.
- Supported by customer reviews and publications.
Medchemexpress LLC APL180 TFA (L-4F TFA) | 98.8% | 2310.60 (free base) | 25 MG
APL180 TFA (L-4F) is an apolipoprotein AI mimetic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL). APL180 can be used in the study of cardiovascular diseases.
- Apolipoprotein AI mimetic peptide
- Enhances the anti-inflammatory activity of high-density lipoprotein (HDL)
- Can be used in the study of cardiovascular diseases
Medchemexpress LLC Valylleucine TFA | 27530-02-5 | 99.3% | 344.33 | 25 MG
Valylleucine TFA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. It can be used for protein interaction, functional analysis, and epitope screening, especially in agent research and development.
- Polypeptide
- Used in peptide screening
- Pools active peptides by immunoassay
- Supports protein interaction studies
- Enables functional analysis
- Facilitates epitope screening
- Applicable in agent research and development
Medchemexpress LLC G-Pen-GRGDSPCA TFA | 111844-17-8 | 948.04 | 1 MG
G-Pen-GRGDSPCA TFA is a peptide identified by its CAS number 111844-17-8. It has a molecular weight of 948.04 and its molecular formula is C35H57N13O14S2. This compound is characterized by the IUPAC Condensed sequence H-Gly-Pen(1)-Gly-Arg-Gly-Asp-Ser-Pro-Cys(1)-Ala-OH.
- Peptide with the sequence GXGRGDSPCA
- Molecular formula C35H57N13O14S2
- Bicyclic heptapeptide structure with disulfide bonds