Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
TARGETMOL CHEMICALS INC 6H05 TFA 5MG
Also available in 1mg 2mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. 6H05 TFA (6H05 trifluoroacetate) is a selective and allosteric oncogenic mutant K-Ras(G12C) inhibitor. purity: 98%
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC REDV TFA | >99.81% | 517.53 | 25 MG
REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. It mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1 (α4β1). This peptide can be utilized in the research of cell adhesion.
- Target: Integrin
- Pathway: Cytoskeleton
- Storage (powder): -80°C for 2 years, -20°C for 1 year (sealed, away from moisture and light)
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month (sealed, away from moisture and light)
- Solubility (in vitro): H₂O: 100 mg/mL (requires ultrasonic)
- Biological activity: Mediates adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(a4β1)
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 | 5 MG
MPSD TFA is the TFA salt form of MPSD, a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe to study membrane curvature and lipid composition, specifically recognizing phosphatidylserine.
- TFA salt form of MPSD
- 25-amino acid peptide
- Derived from MARCKS protein
- Detects membrane curvature
- Identifies phosphatidylserine
- Useful as a biological probe
- White to off-white solid appearance
- Soluble in DMSO and H2O
Medchemexpress LLC Fti-276 trifluoroacetate | 1217471-51-6 | 98.0% | 547.6 g/mol | C23H28F3N3O5S2 | 10 MG
FTI-276 trifluoroacetate is the trifluoroacetate salt of a small-molecule inhibitor of protein farnesyl transferase. It is provided as a solid for research use and exhibits sub-nanomolar activity against both Plasmodium falciparum and human PFT, making it suitable for biochemical and antiparasitic research applications.
- Potent protein farnesyl transferase inhibition at sub-nanomolar concentrations.
- Provided as the trifluoroacetate (TFA) salt to aid handling and formulation.
- High reported purity, approximately 98%.
- Supplied in small, research-ready quantities suitable for assay development.
- Characterized by published chemical identifiers for unambiguous compound identification.
Medchemexpress LLC Frakefamide TFA 10mM 1mL | 10MM 1ML
Frakefamide TFA is a potent analgesic that acts as a peripheral active -selective receptor agonist Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1 [2
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 1 MG
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Tetrapeptide
- Selective and irreversible MALT1 inhibitor
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Ile-AMS TFA | 219931-45-0 | MFCD31619268 | 98.6% | 572.52 g/mol | C18H27F3N8O8S | 10 MG
Ile-AMS TFA is the trifluoroacetic acid (TFA) salt of an aminoacyl-sulfamoyl adenosine analogue that inhibits isoleucyl-tRNA synthetase and displays potent antiparasitic activity (P. falciparum ABS IC50 = 1.19 nM). Intended for laboratory research use only.
- Purity 98.55%.
- Molecular weight 572.52 g/mol; chemical formula C18H27F3N8O8S.
- Soluble in water (≈100 mg/mL); ultrasonic assistance may be required.
- Recommended storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Available in small research quantities, including a 10 mg package.
- Used as a tool compound for studies of aminoacyl-tRNA synthetase inhibition and antiparasitic research.
Medchemexpress LLC TD-0212 TFA 10mM | 10MM 1ML
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor with a pKi of 8 9 for AT1 and a pIC50 of 9 2 for NEP[1]
Medchemexpress LLC Fn-439 TFA | 124168-73-6 | MFCD00237459 | 99.8% | 604.58 g·mol⁻¹ | C25H35F3N6O8 | 5 MG
FN-439 TFA is the trifluoroacetic acid salt of FN-439, a selective small-molecule inhibitor of collagenase-1 (matrix metalloproteinase). It inhibits collagenase-1 with an IC50 of 1 μM and is supplied as a research reagent for in vitro studies of cancer and inflammatory processes.
- Selective collagenase-1 inhibitor with reported IC50 of 1 μM.
- High purity (99.81%) suitable for biochemical assays.
- Trifluoroacetic acid salt form to aid solubility in aqueous systems.
- Supplied in research-scale quantities (e.g., five mg) for assay development.
- Intended for in vitro research applications; not for human use.
Medchemexpress LLC DLPLTFGGGTK TFA | MFCD34187350 | 98.1% | 1219.26 | 1 MG
DLPLTFGGGTK TFA is a synthetic peptide, presented as a white to off-white solid. It is a surrogate peptide for pembrolizumab identification and has been tested to comply with given specifications. This high-purity product (98.11%) is intended for research use only.
- White to off-white solid
- Surrogate peptide for pembrolizumab identification
- High purity of 98.11%
- Molecular weight of 1219.26
- Intended for research use
Medchemexpress LLC LL-37 amide TFA | 99.3% | 4492.28 | 10 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effective in inhibiting periodontal pathogens. It functions by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. This modified form of LL-37 also regulates inflammatory responses, promotes angiogenesis, and shows improved stability and enhanced resistance to enzymatic degradation compared to natural LL-37.
- Effective against periodontal pathogens
- Activates FPRL1-mediated immune cell chemotaxis
- Disrupts bacterial cell membrane integrity
- Regulates inflammatory responses and promotes angiogenesis
- Improved stability and resistance to enzymatic degradation
- Good antibacterial effects against Gram-positive and Gram-negative bacteria
- Used in research for infection-related diseases and wound healing
Medchemexpress LLC JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
JPS016 (TFA) | 99.5% | C50H64F3N7O10S | 1 MG
Medchemexpress LLC RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG